Skip To Main Content

COVID-19 Updates and Resources. Learn More

Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction

Summary:

Background

Diets that restrict carbohydrate (CHO) have proven to be a successful dietary treatment of obesity for many people, but the degree of weight loss varies across individuals. The extent to which genetic factors associate with the magnitude of weight loss induced by CHO restriction is unknown. We examined associations among polymorphisms in candidate genes and weight loss in order to understand the physiological factors influencing body weight responses to CHO restriction.

Methods

We screened for genetic associations with weight loss in 86 healthy adults who were instructed to restrict CHO to a level that induced a small level of ketosis (CHO ~10% of total energy). A total of 27 single nucleotide polymorphisms (SNPs) were selected from 15 candidate genes involved in fat digestion/metabolism, intracellular glucose metabolism, lipoprotein remodeling, and appetite regulation. Multiple linear regression was used to rank the SNPs according to probability of association, and the most significant associations were analyzed in greater detail.

Results

Mean weight loss was 6.4 kg. SNPs in the gastric lipase (LIPF), hepatic glycogen synthase (GYS2), cholesteryl ester transfer protein (CETP) and galanin (GAL) genes were significantly associated with weight loss.

Conclusion

A strong association between weight loss induced by dietary CHO restriction and variability in genes regulating fat digestion, hepatic glucose metabolism, intravascular lipoprotein remodeling, and appetite were detected. These discoveries could provide clues to important physiologic adaptations underlying the body mass response to CHO restriction.

Commentary:

The electronic version of this article is the complete one and can be found online at:http://www.nutritionandmetabolism.com/content/3/1/20

Try Keto – The Atkins® Way

Atkins keto plans are more flexible and more personalized to provide a long-term plan for reaching your goals. Our free tools can help you even further.

Get Started

Learn More AboutArticles

How To Make Low Carb Crockpot Recipes this Winter

Less time spent cooking this winter means more time to yourself.

Lire la suite »

Low Carb Mother's Day Brunch Ideas & Recipes

For all the work they do, it seems crazy that mothers only get one day a year.

Lire la suite »

National Pomegranate Month

There are plenty of reasons to eat pomegranate.

Lire la suite »

Low Carb Halloween Recipes & Recipe Ideas

Halloween is scary—especially when you’re on a low carb diet and surrounded by candy with nowhere to escape.

Lire la suite »

This site uses essential cookies to function. It also uses non-essential cookies for marketing and advertising. For more information please see ourPrivacy Policy.

This site uses essential cookies to function. It also uses non-essential cookies for marketing and advertising. For more information please see ourPrivacy Policy.

Close button